How about Rosie O'Donnell as Peter in a Family Guy movie?

Now that The Simpsons has made a successful jump from the small screen to the big (a billion bucks worldwide so far!), people are talking about bringing another FOX animated series, Family Guy, to your local theater as well. But does it have enough of an audience for such a project?

Seth MacFarlane isn't sure, but he has a live-action cast picked out. Rosie O'Donnell would be Peter (a very scary Peter), David Hyde Pierce would be Stewie (?), Ann Coulter would be Brian, Phillip Seymour Hoffman would play Chris, Juliette Lewis would be Meg, and Kathy Griffin would portray Lois.

Of course, he's kidding, but it's fun to speculate. Who would you cast in the main roles, or should they just be played by the actors who voice them? And what Cleveland and Quagmire? I can't picture anyone else playing Joe besides Patrick Warburton.