Pee Wee's Playhouse: The Movie, staring ... Johnny Depp?
The script would be by Paul Reubens, the original Pee-Wee. The two actors have known each other for a while, having worked together in the 2001 movie Blow. Also, both are casting favorites of director Tim Burton (Burton's professional directorial debut was the movie Pee-Wee's Big Adventure).
I don't know if this is going to happen, but it has a better shot than most Hollywood rumors. I think Depp is good in most of his roles and would be able to duplicate the maniacal glee of playing Pee-Wee. Of course, any actor would play any role for the right price (with rare exceptions).
I still remember Pee-Wee's Playhouse from when it was an adult-oriented show on HBO. I wonder if the movie will go the kid's show route or play more for adults?