What to Watch Tuesday, Sept. 16

'House'
(8PM, Fox) 5th season premiere
Could this be the end of the House/Wilson bromance? Still reeling from the death of his beloved Amber, Wilson resigns from the hospital and puts his friendship with haughty House on hold.

House wonders if he is to blame for Amber not surviving the bus crash, and with Wilson re-evaluating whether or not this latest incident is just part of a pattern of House's destructive influence on his life, Dr. Crabby could indeed lose his only real pal.

Elsewhere at Princeton-Plainsboro, House is suspicious about Thirteen's interest in the case of a workaholic businesswoman, but the mysterious doc may have something surprising in common with her patient.


'House'
(8PM, Fox) 5th season premiere
Could this be the end of the House/Wilson bromance? Still reeling from the death of his beloved Amber, Wilson resigns from the hospital and puts his friendship with haughty House on hold.

House wonders if he is to blame for Amber not surviving the bus crash, and with Wilson re-evaluating whether or not this latest incident is just part of a pattern of House's destructive influence on his life, Dr. Crabby could indeed lose his only real pal.

Elsewhere at Princeton-Plainsboro, House is suspicious about Thirteen's interest in the case of a workaholic businesswoman, but the mysterious doc may have something surprising in common with her patient.

'The Biggest Loser: Families'
(8PM, NBC) 6th season premiere
This season's competition pits teams of hubbies and wives against teams of 'rents and their adult kids.

'Big Brother 10'
(9PM, CBS) 10th season finale
For years afterwards, viewers will talk about where they were the night they found out which dude won 'Big Brother 10.' Or not.

'Lincoln Heights'
(8PM, ABC Family) 3rd season premiere
When Jenn and Eddie are away, the bad guys will play ... as in, breaking into Casa Sutton and taking Cassie and Charles hostage.

'Whatever, Martha!'
(9PM, Fine Living) series premiere
Alexis Stewart says it was her mom's idea for Alexis and her pal Jennifer to goof on Martha's old 1990s shows in this new weekly series. Okay, Alexis, but you'll only have yourself to blame if your inheritance takes a hit.

'90210'
(8PM, The CW)
Brenda and Kelly are fighting, Dixon's taking a job at The Peach Pit with Nat ... if Erin Silver would just start playing the keyboard and writing bad R&B music, we'd be partying like it was 1992.

'Wipeout'
(8PM, ABC) 1st season finale
Farewell for now, Big Balls, Sucker Punch and The Sweeper. We'll miss ye.

'Greek'
(9PM, ABC Family)
Calvin's gaydar failed him, because he is very surprised by who he sees when he and his boyfriend go to a gay bar.


What's on tomorrow: 'Project Runway,' 'Bones' and more

Check out our TV calendar for a look at the month ahead