Sissy Spacek is moving from sabotaging polygamists to saving the world.

According to the Hollywood Reporter, the Oscar-winning actress will follow up her role as the duplicitous lobbyist Marilyn Densham on HBO's 'Big Love' by playing the lead in a medical drama pilot for CBS, produced by John Wells ('ER'; 'Southland').

The pilot centers around a crew of mobile medical professionals who travel the globe in search of those in need of treatment. Spacek will play the group leader -- a role originally written for a male lead -- who has a tireless, demanding work ethic despite undergoing cancer treatments.Sissy Spacek is moving from sabotaging polygamists to saving the world.

According to the Hollywood Reporter, the Oscar-winning actress will follow up her role as the duplicitous lobbyist Marilyn Densham on HBO's 'Big Love' by playing the lead in a medical drama pilot for CBS, produced by John Wells ('ER'; 'Southland').

The pilot centers around a crew of mobile medical professionals who travel the globe in search of those in need of treatment. Spacek will play the group leader -- a role originally written for a male lead -- who has a tireless, demanding work ethic despite undergoing cancer treatments.

'Twilght's' Rachelle Lefevre will play Spacek's daughter, who joins the medical team.

Amy Smart, Janeane Garofalo and Skeet Ulrich co-star.

Though there's no word yet on the project's title, the pilot will be directed by Christopher Chulack and written by Hannah Shakespeare.