Isla Fisher Almost Kissed Johnny Depp During the Filming of 'Rango' (VIDEO)

'Rango' is an animated film that has a very distinct and different look from most of the computer-animated movies we've seen. It also had a rather different filmmaking process as well, according to Isla Fisher on 'Chelsea Lately' (Weeknights 11PM ET on E!).

Chelsea Handler assumed it was like most animated movies, with the actors isolated in their sound booths reading out their lines, but the production was much more active than that. "We actually shot this a little like a play," Fisher said. "We were on a sound stage and we acted it out. You know, we got to react off of each other."

Handler was determined to imagine Fisher showing up with no hair and make-up in her PJs, but that wasn't the case. "I was working with Johnny Depp, so I did make some effort."

Unfortunately, Fisher missed out on a rare opportunity. Because of the different method of recording the voice work, she had an actual kissing scene scheduled with Depp. But her glands were swollen and she didn't want to give him a cold.

"I would have just went ahead and given him whatever I had," Handler said. Based on Fisher's reaction to her own story, we think she kind of wishes she had.

Watch Isla Fisher's full interview here: