'Mike & Molly' star Melissa McCarthy and host Chelsea Handler swapped tips for making their co-stars crack up, on 'Chelsea Lately' (Weeknights, 11PM ET on E!).

McCarthy had stopped by to talk about her new movie, 'Bridesmaids,' and said that she'd gone after one particular actress "pretty hard."

After Chelsea said that "when I'm on set I like to make people not say their lines right," McCarthy confessed that she'd targeted Rose Byrne, who plays the "Stepfordish" Helen in the movie.

"I really went after Rose. ... She's just so pretty and I look like such a man in it." McCarthy then joked that she's now more than capable of taking on male roles. So we're wondering if maybe her 'Bridesmaids' producer Judd Apatow could find a part for her in his next bromance.

Watch the full interview here: