Chelsea Handler's MTV Awards Joke Got Joe Manganiello in Trouble With His Family (VIDEO)

When Joe Manganiello joined the cast of 'True Blood' as friendly werewolf Alcide, he was entering a world of sex and supernatural craziness that's almost unprecedented on television. And yet, it was comments by one Chelsea Handler that caused the most stir in his family, according to what he said on 'Chelsea Lately' (Weeknights, 11PM ET on E!).

"I know at the MTV Movie Awards I made a joke about sitting on your face or something, and I know she was upset," Handler said of Manganiello's fiancé. That's why she was sure to clarify to her audience that he was off the market.

But that joke, which Manganiello didn't even hear -- he was backstage at the time -- caused more than just drama with his fiancé.

"The morning after the Movie Awards, I get a call from my mom: 'Oh my God, that's disgusting.'" Manganiello said. Nothing that has ever happened on the show elicited a response from his mother, but this joke got her attention.