If we were making a list of greatest celebrity comebacks of 2011, then Christina Applegate would definitely be at the top of the list. It just so happens that she also happens to be one of the funniest ladies in the biz. Her role as panicky new mom Reagan Brinkley is somewhat impulsively crazy without being too over-the-top (leave that to Maya Rudolph). But let's not forget that Applegate has one of the most colorful careers in comedy TV, having played the fabulously clueless Kelly Bundy on 'Married... With Children' and the equally zany Samantha in ABC's short-lived comedy, 'Samantha Who?' With Applegate being a new mom herself in 2011, Reagan's struggle between constant exhaustion and frantic joy seems pretty authentic.