Starring: Patrick Wilson as brilliant Manhattan surgeon Michael Holt; Jennifer Ehle as his ex-wife, do-gooding doctor Anna; Julie Benz as his quirky, single mom sister Christina; and 'Justified' Emmy nominee Margo Martindale as his super-efficient assistant Rita

What It's About: Dr. Michael is obsessed with work and his wealthy patients, but when he begins communicating with his idealistic ex -- make that, her spirit, since she just died -- he gets bitten by the altruistic bug and, egged on by Anna's presence, does some do-gooding of his own.

Premieres Fri., Sept. 23, 8PM ET on CBS