Starring: Will Arnett and Christina Applegate as new parents Chris and Reagan; Maya Rudolph as Ava, Reagan’s talk show host boss; and Nick Cannon as Ava's talk show co-host

What It’s About: Yes, we’ve all seen new parents struggling to balance it all and still have their own lives … but never like this. Arguably the best, funniest and most natural roles for all three stars. We'll have to wait and see how new addition Cannon fits into the mix.

Premieres Wed., Sept. 14, 10PM ET on NBC