Krista Starr returns from Iraq to learn that her twin brother, Zack, has died under mysterious circumstances. Krista soon meets Blade, as well as the killer himself, Marcus Van Sciver, a powerful vampire who becomes smitten with her, turning her into a vampire by injecting her with his blood. Blade then injects her with the same serum he uses to control his own vampire instincts. Blade offers Krista a chance to help avenge her brother's death and bring down Marcus. The series is based on the comic-book character Blade and the series of movies featuring him.