In a Manhattan real estate office, four very different women cater to high-end clients while coping with their own personal predicaments. Married to a handsome 25-year-old, 40-something Ava Summerlin wants to start a family, while self-improvement junkie Chloe would settle for any guy who can remember her the next day. Recently divorced after being married ten years to a gay man, voluptuous Lola dreads jumping back into the dating pool, and the latest addition to this eclectic work group is rich girl Emerson Ives, who instantly bonds with the women upon learning that her supposedly virginal fiancee was anything but. And the ladies' office neighbors from down the hall, therapist Dr. Sellers Boyd and plastic surgeon Dr. Charlie Thorpe, help keep things lively around the water cooler.