"Dewey Defeats Truman," at least according to an erroneous front-page headline of a 1948 issue of the Chicago Tribune. But if Thomas E. Dewey had won that year's presidential election, he wouldn't be featured in an episode of this series, which highlights the impact that losing presidential candidates have had on American politics. Each episode puts the spotlight on a political figure who won a national party's nomination in at least one presidential election but didn't win the general election. Each man's impact on politics is examined and each one is made relevant to the modern political landscape. In addition to Dewey, other candidates featured in the 90-minute episodes include William Jennings Bryan, Barry Goldwater, George Wallace and Ross Perot.