I watched the first ten minutes of this episode last night and that's it, so I'm not sure what the 42 in the episode title refers to. I know that it has something to do with weird happenings/coincidences that happen to Harold Perrineau's character. Can I also assume it's a reference to Douglas Adam's The Hitchhiker's Guide To The Galaxy?

Fox Mulder's apartment number was 42, if I remember correctly ...