'Family Guy' fans have suffered a huge loss -- and an even bigger gain. Giggly neighbor Cleveland Brown has left Quahog for his old hometown in Stoolbend, Indiana, adding a new show of his own to Fox's Sunday night animation lineup.

With Cleveland Jr. in tow, Cleveland's got a new wife, a couple of rowdy stepkids and, of course, some very interesting (and very diverse) new neighbors, which all comes together to make 'The Cleveland Show' (premieres Sun., Sept. 27, 8:30PM ET on Fox).

We got creators Rich Appel and Mike Henry -- who is also the voice of Cleveland, among other characters -- to tell us how 'Cleveland' is different from 'Family Guy,' which episodes are their favorites and what it was like working with Kanye West. (Shocker: He arrived early!)

Oh, Peter. They're breaking up that old gang of ours! There's a spin-off of Family Guy in the works at Fox. Peter's drinking buddy, Cleveland Brown, might be getting his own show. Oh no, does this mean he may be leaving Quahog? What, no more get-togethers at The Drunken Clam? (Note to self: He's an animated character; he could still be part of Family Guy.)

Cleveland is perhaps the most down to earth of Peter's pals on Family Guy, which could make him the perfect centerpiece of a new cartoon series. Zany new characters could be built around him. If history repeats itself, he could be the George Jefferson to Peter Griffin's Archie Bunker, i.e., The Jeffersons spinning off from All in the Family.