In case you weren't buying the rumors that the character of Gregory House, M.D. was very much based on Arthur Conan Doyle's Sherlock Holmes, the deal was pretty much sealed when our beloved curmudgeon took a bullet to the gut care of Jack Moriarty at the close of season two. Moriarty is also the namesake of the nemesis that took Sherlock over the cliff with him in the short story The Final Problem. But with our House and Holmes, it's the inner demons that really torment.

Here's a blow-by-blow on the House-Holmes connection: