As a Firefly fan, I'll lead this story with the Nathan Fillion news. Fillion is reportedly in negotiations for a starring role in an ABC comedy called Castle. It's described as a "comedic procedural about a famous mystery novelist helping the NYPD solve crimes". Fillion is up for the role of that famous novelist. That sounds like his cup of tea, doesn't it? He has comedy in his blood, but can also bring on the drama when necessary. Currently, Fillion has a recurring role on Desperate Housewives and just finished filming a movie called Chilled in Miami.

Alyssa Milano currently has a recurring role on My Name is Earl (I assume she's still there -- haven't seen last night's episode yet). She is in talks to star in an untitled project for ABC about a young woman "who tries to break free of her overbearing and dysfunctional family, friends and boss." It's a single-camera comedy. Kind-of sounds like Samantha Who? but without the amnesia schick.