With Charlie Sheen's very public meltdown happening during the filming of the latest season of 'Two and a Half Men,' David Letterman was curious if co-star Jon Cryer or anyone else on the show saw any of this coming. On 'Late Show' (Weeknights, 11:35PM ET on CBS), Cryer said nobody did.

"This has never happened before," Cryer said. There was no template for a star going what appeared to be crazy while starring in a popular show before.

"It wasn't like, 'Back in 1963 everybody remembers when Fred MacMurray went bats*** and started talking about freemason ninjas and stuff. He was crazy! And Vivian Vance started urinating on the set of 'Here's Lucy.''"

Is it time for yet another Charlie Sheen meltdown? After it was announced last week that Ashton Kutcher would be replacing him in 'Two and a Half Men,' Sheen was quick to publicly mock the decision. He called the star of 'That '70s Show' a "sweetheart," but added that Kutcher would bring the show down.

However, despite his public show of gravitas, a source close to Sheen tells Popeater that privately he's "destroyed" by the casting news.

"He really thought that he would be invited back," a friend of Charlie's tells me. "After years of suffering no consequences for his behavior, why would he think anything else? Finally it has sunk in that he doesn't live by different rules to everyone else. Actions do have a consequences."

Yes, you read that right. British actor Hugh Grant, all-around posh boy and rom-com A-lister has reportedly been in talks to replace Charlie Sheen in 'Two and a Half Men.'

According to Deadline, the 'Bridget Jones' star first entered the running about a month ago when CBS boss Les Moonves and President Nina Tassler approved him as a candidate.

Warner Bros. Studio execs and 'Men' creator Chuck Lorre have been searching for a way to continue the money-spinning comedy without Sheen, and word is that they're still looking for a solid A-lister.

Deadline reports that after being offered $1 million per episode, Grant was close to signing a deal when he backed out unexpectedly, supposely because he balked at the demanding work schedule of a weekly TV series.

It's been a busy 24 hours in the world of Charlie Sheen. Since being fired by Warner Bros. yesterday for alleged "moral turpitude," Sheen's gone on the offensive. And how.

He's unleashed some "Truth Torpedoes" online, he's downed a bottle of "tiger blood," wielded a machete whilst yelling "Free at last!", advertised for a "winning" intern (form an orderly line), said he was fired by text and claimed that his termination breaches the terms of his contract.

So what's going on? Why was he fired? How was he fired? And does he really have a "Michael J. Fox" clause in his contract?

All will be revealed after the jump ...

The war of words continues between Charlie Sheen and Les Moonves. And hey, now super-producer Harvey Weinstein has weighed in on which one's playing "a losing game." (Hint: It's not Les Moonves.)

Yesterday we reported how CBS boss Moonves had spoken out at a business conference, criticizing the actor's conduct. Moonves said he wished that Sheen had "worked [as] hard to promote himself for an Emmy," as he did bringing his dispute with 'Two and a Half Men' to the media.

So what exactly did Sheen make of it? In an interview with Access Hollywood, Sheen told Billy Bush, "That's funny. That's good, a good joke." And as for Moonves's assertion that CBS is still making money off of his sitcom, Sheen says that he wants a piece of the action.

During the increasingly bitter Charlie Sheen–vs.–Chuck Lorre–and-CBS public feud, both sides have slung insults at each other with abandon. Lorre called Sheen "a degenerate," and Sheen responded with a whole bunch of slurs.

In recent days Lorre vowed to stop writing his trademark "vanity cards" and has since remained silent, but now, following Sheen's marathon round of TV interviews, he's broken his silence ... Kind of.

Eagle-eyed viewers spotted a rambling rant on one of Lorre's famous vanity cards in the closing credits for his other show, 'Mike & Molly,' last night. Reading like a riposte to some of Sheen's odder pronouncements in recent days, it ends "I am so outta here!"

The vanity card came two weeks after Lorre posted a provocative one in the closing credits for the last episode of 'Two and a Half Men.' That one read "If Charlie Sheen outlives me, I'm gonna be really pissed."

Charlie's Sheen's whirlwind media tour continued on 'Piers Morgan Tonight' (Weeknights, 9PM ET on CNN), where he sat down for his first live television interview since the recent controversy erupted.

He was a bit more contrite then he had been in interviews aired earlier in the day. He backed off from the financial demands he had been making of CBS, and he apologized for a remark he made about 'Two And A Half Men' co-creator Chuck Lorre that was perceived by some to be anti-Semitic.

But Sheen remained fairly unrepentant about the wild lifestyle he's led.

"If you had your time again, would you ever get into drugs?" Morgan wondered.

Last week radio listeners got more than an earful of Charlie Sheen's rantings and ravings, and now TV viewers can also get in on the act.

It's been reported that the 'Two and a Half Men' star caused even more controversy over the weekend by giving interviews to not one but two TV networks, with the each racing the other to be the first to air this morning.

First, he sat down Saturday with ABC's Andrea Canning, in what the network said was "an exclusive" interview. ABC ran promos for it during last night's Oscars telecast, and planned to air the interview in segments of 'Good Morning America' Monday and Tuesday, with a one-hour special Tuesday night at 10PM ET.

But then he gave another interview, this time to NBC's Jeff Rossen, on Sunday. And in a move that The Hollywood Reporter says resulted in "apoplexy" over at ABC News, the rival network said it will air the interview during early segments of this morning's 'Today' show.

The latest chapter in the ongoing Charlie Sheen saga comes in book form: namely, the proposed tell-all that Sheen told TMZ he plans on writing about what went on behind the scenes of 'Two and a Half Men.'

Sheen said he wants to call his book 'When the Laughter Stopped' (which also happens to be the name of a post-'Diff'rent Strokes' TV movie and a Slate article about Bob Hope), and he expects publishers to start a bidding war at $10 million.

TMZ reports that Sheen "plans on naming names -- including co-stars."

UPDATE: According to TV Line, Sheen plans to sit down with ABC News for an exclusive interview tentatively scheduled to air Tuesday night at 10PM. ABC has yet to confirm.

"I'm not normal," Charlie Sheen told Pat O'Brien Friday afternoon in one of the troubled actor's now-regular radio rants.

Sheen called into O'Brien's Fox Sports Radio show to discuss ... well, pretty much the same things he's been talking about all week. This time, he called 'Two and a Half Men' "drivel" and a "pukefest that everybody worships." After the jump, find out why Sheen's not planning on attending the Oscars and what, exactly, he was allegedly working on with HBO.

Charlie Sheen's rant heard 'round the Internet already caused the production on 'Two and a Half Men' to shut down, but that's just the beginning of the aftermath. His meltdown leads to a ton of other questions, not the least of which is: Does this mean 'Two and a Half Men' will be cancelled?

We all knew that this was going to happen, but we didn't know it was going to happen in such an entertaining way.

As my fellow Squadder Mo Ryan reported yesterday, CBS pulled the plug on the rest of the mega-hit sitcom's season based on "the totality of Charlie Sheen's statements, conduct and condition," which was likely code for "He's gone off the deep end and we can't deal with it anymore."

Given his latest statements to TMZ and the Alex Jones radio show, many of which were directly aimed at "Chaim Levine," a not-so-subtle and vaguely anti-Semitic reference to producer Chuck Lorre's given name, CBS and Warner Brothers really had no choice.

Charlie Sheen's rant on the Alex Jones radio show was aired, in part, on 'The Early Show' (weekdays, 7AM ET on CBS). The now-infamous rant reportedly contributed to CBS' decision to shelve 'Two and a Half Men' for the remainder of the season.

In yesterday's radio interview, Sheen takes aim at the sitcom's co-creator, Chuck Lorre, referring to him by his Hebrew name and promising to "destroy" him in a rambling, but exceedingly colorful, way.