(S11E06)

Mrs. Garrison: Kids, I need to tell you something that you might find a little shocking: I'm gay.

Stan: Again?

Longtime fans of South Park know that Mr./Ms. Garrison is a mercurial sexual beast. S/he's now been both straight and gay as a man and as a woman, but the one constant that remains is that whatever her preference happens to be that week, she takes it very seriously.