(S03E02) Okay, I'm going to go out on a limb here and say that I don't think Orson killed his wife. What do you think? I mean, seriously, he may be clean in a creepy way-- but so is Bree. The woman's body was not his missing wife's-- though he clearly knew the woman, based on his saying something to her and calling her "Monique" as he left the morgue.

So, is this another missing wife? Maybe, but we don't know that.